Intricate Link between Autophagy and Amyloid-β Kinetics: Modeling and Simulations

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

mTOR, AMBRA1, and autophagy: An intricate relationship

Autophagy is the primary catabolic cellular degradation process, which generates nutrients and energy to maintain essential cellular activities upon nutrient starvation. The regulation of autophagy is central to the understanding of its mechanisms; post-translational modifications account for the rapid kinetics that control autophagy induction. A recent paper of ours provided 2 important insigh...

متن کامل

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.

A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise mechanism remains unclear, T2D can exacerbate neurodegenerative processes. Brain atrophy, reduced cerebral glucose metabolism, and central nervous system insulin resistance are features of both AD and T2D. The T2D phenotype (glucose dys...

متن کامل

the relationship between topic familiarity and guessing lexical meaning and retention among iranian efl learners

the skill of reading in english as a foreign language is an important and challenging one which is affected both by linguistic and extra linguistic factors. since vocabularies are part and parcel of every reading comprehension text, knowing enough vocabulary always facilitates this process. however, guessing strategy as one of the most important strategies has consistently ignored by language l...

15 صفحه اول

CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.

BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering of CNS amyloid-β (Aβ) levels. The interaction of the β-secretase and α-secretase pathway-mediated processing of APP in the rhesus monkey (nonhuman pr...

متن کامل

SIRTing out the link between autophagy and ageing.

Correspondence and offprint requests to: Michael S. Goligorsky; E-mail: [email protected] Comment on Hartleben B, Godel M, Meyer-Schwesinger C et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010; 120: 1084–1096. Kume S, Uzu T, Horiike K et al. Calorie restriction enhances cell adaptation to hypoxia through ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2019

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2018.11.2277